By A Mystery Man Writer
The objectives of this study were to evaluate the delamination of convex-shaped metformin HCl (MF) and evogliptin tartrate (EG) multi-layer tablets depending on the pre-compression and main compression pressures and simultaneously correlate these results with those of a surface roughness analysis. Free-flowing MF and EG (median diameters of 38.3 and 44.7 μm, respectively) granules prepared using the wet granulation method were pre-compressed and subsequently compressed into bilayer and trilayer tablets using a universal testing machine. The compaction force required to break the tablets increased linearly as the main compression pressure increased (30–150 MPa). Conversely, the interfacial strength and compaction breaking force decreased as the pre-compression pressure increased (10–110 MPa). A surface roughness analysis employing a profilometer revealed that the first layer (MF) roughness drastically decreased from 5.89 to 0.51 μm (Ra, arithmetic average of profile height deviations from the mean line) as the pre-compression pressure increased from 10 to 150 MPa in the bilayer tablet. Accordingly, the decrease in the roughness of the first layer reduced the inter-penetration at the interface, as observed via energy dispersive spectrometer (EDS)-equipped scanning electron microscopy, decreasing the interfacial bonding strength and causing delamination of the MF/EG multi-layer tablets. These findings indicate the significance of roughness control in the actual preparation of multi-layer tablets and the usefulness of profilometer- and EDS-based surface analyses for interpreting the delamination of multi-layer tablets.
A view on drug resistance in cancer
Buy OZONE Ozone Signature Leave In Hair Serum 30 ML
Pharmaceuticals, Free Full-Text
Pharmaceuticals, Free Full-Text
Lack of effect of pantoprazole on the pharmacodynamics and
Pharmaceuticals, Free Full-Text
Gcase Activator
Pharmaceuticals, Free Full-Text
PDF] Direct-to-consumer advertising of pharmaceuticals.
NeilMed Pharmaceuticals Sinus Rinse Packets, All Natural Relief
Pharmaceuticals, Free Full-Text
FABRX on LinkedIn: A Bibliometric Analysis of 3D Printing in
Pharmaceuticals, Free Full-Text, igor's costela
ACCELERATE Platform Innovation for Children with Cancer, accelerate